心房颤动的基因组学
Genomics of Atrial Fibrillation.
作者信息
Gutierrez Alejandra, Chung Mina K
机构信息
Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA.
Department of Cardiovascular Medicine, Heart & Vascular Institute, Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., J2-2, Cleveland, OH, 44195, USA.
出版信息
Curr Cardiol Rep. 2016 Jun;18(6):55. doi: 10.1007/s11886-016-0735-8.
Atrial fibrillation (AF) is a common clinical arrhythmia that appears to be highly heritable, despite representing a complex interplay of several disease processes that generally do not manifest until later in life. In this manuscript, we will review the genetic basis of this complex trait established through studies of familial AF, linkage and candidate gene studies of common AF, genome wide association studies (GWAS) of common AF, and transcriptomic studies of AF. Since AF is associated with a five-fold increase in the risk of stroke, we also review the intersection of common genetic factors associated with both of these conditions. Similarly, we highlight the intersection of common genetic markers associated with some risk factors for AF, such as hypertension and obesity, and AF. Lastly, we describe a paradigm where genetic factors predispose to the risk of AF, but which may require additional stress and trigger factors in older age to allow for the clinical manifestation of AF.
心房颤动（AF）是一种常见的临床心律失常，尽管它代表了几种通常在生命后期才会显现的疾病过程之间的复杂相互作用，但似乎具有高度遗传性。在本手稿中，我们将回顾通过家族性房颤研究、常见房颤的连锁和候选基因研究、常见房颤的全基因组关联研究（GWAS）以及房颤的转录组学研究所确立的这一复杂性状的遗传基础。由于房颤与中风风险增加五倍相关，我们还将回顾与这两种疾病相关的常见遗传因素的交集。同样，我们强调与房颤的一些危险因素（如高血压和肥胖）以及房颤相关的常见遗传标记的交集。最后，我们描述了一种模式，即遗传因素使个体易患房颤风险，但可能需要在老年时额外的应激和触发因素才能使房颤临床表现出来。
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