Polla B S
Allergy Unit, University Hospital, Geneva, Switzerland.
Immunol Today. 1991 Mar;12(3):A38-41. doi: 10.1016/S0167-5699(05)80011-8.
For most living organisms, heat shock represents an unusual stress situation, but for parasites that are transmitted between invertebrate vectors and mammalian hosts it is a frequent physiological occurrence. Because of the extraordinary conservation of heat shock proteins (HSPs) and their potential immunogenicity, much attention has recently focused on the role of HSPs in infection and immunity. In parasites, HSPs appear to play specific functions in differentiation, in protection from the host cell's killing mechanisms, including oxygen free radicals, and even in virulence. In this article, Barbara Polla uses the example of malaria to illustrate the possible role of HSPs in host-parasite relationships.
对于大多数生物来说，热休克代表一种异常的应激情况，但对于在无脊椎动物媒介和哺乳动物宿主之间传播的寄生虫而言，这却是一种常见的生理现象。由于热休克蛋白（HSPs）具有高度保守性及其潜在的免疫原性，最近人们将大量注意力集中在了热休克蛋白在感染和免疫中的作用上。在寄生虫中，热休克蛋白似乎在分化过程中、在抵御宿主细胞的杀伤机制（包括氧自由基）甚至在毒力方面发挥着特定功能。在本文中，芭芭拉·波拉以疟疾为例来说明热休克蛋白在宿主-寄生虫关系中可能发挥的作用。
