Park Sul, Jung Jae Jin, Kim Goeng Bae, Yoon Hyung Sik, Ko Sang Hun, Ko Jae Ee, Lee Yeun Seun
Department of Internal Medicine, Sun General Hospital, Daejeon, Korea.
Korean J Gastroenterol. 2010 May;55(5):340-3. doi: 10.4166/kjg.2010.55.5.340.
Oxaliplatin with 5-fluorouracil plus leucovorin (FOLFOX) has become the standard treatment in patients with colorectal cancer. Among known toxicities induced by oxaliplatin, hematological, gastrointestinal and neurological toxicities are common. However, acute pulmonary toxicity associated with oxaliplatin is unusual. One case of interstitial lung disease associated with the FOLFOX protocol is reported here.
奥沙利铂联合5-氟尿嘧啶加亚叶酸钙（FOLFOX）已成为结直肠癌患者的标准治疗方案。在奥沙利铂引起的已知毒性中，血液学、胃肠道和神经毒性较为常见。然而，与奥沙利铂相关的急性肺毒性并不常见。本文报告1例与FOLFOX方案相关的间质性肺疾病病例。
