Department of Physiology, Medical School, University of Patras, Patras, Greece.
Cell Cycle. 2010 Aug 15;9(16):3181-5. doi: 10.4161/cc.9.16.12554. Epub 2010 Aug 28.
The interplay of proliferation and differentiation is essential for normal development and organogenesis. Geminin is a cell cycle regulator which controls licensing of origins for DNA replication, safeguarding genomic stability. Geminin has also been shown to regulate cellular decisions of self-renewal versus commitment of neuronal progenitor cells. We discuss here our recent analysis of mice with conditional inactivation of the Geminin gene in the immune system. Our data indicate that Geminin is not indispensable for every cell division: in the absence of Geminin, development of progenitor T cells appears largely unaffected. In contrast, rapid cell divisions, taking place in vitro upon TCR receptor activation or in vivo during homeostatic proliferation, are defective.
增殖和分化的相互作用对于正常发育和器官发生至关重要。Geminin 是一种细胞周期调节剂，可控制 DNA 复制起始点的许可，从而保障基因组的稳定性。Geminin 还被证明可以调节神经祖细胞的自我更新与分化的细胞决策。在这里，我们讨论了我们最近对免疫系统中条件性失活 Geminin 基因的小鼠进行的分析。我们的数据表明，Geminin 并非每个细胞分裂都不可或缺：在没有 Geminin 的情况下，祖 T 细胞的发育似乎基本不受影响。相比之下，T 细胞受体激活体外或体内稳态增殖时发生的快速细胞分裂存在缺陷。
