复制许可与癌症——致命的纠缠？
Replication licensing and cancer--a fatal entanglement?
作者信息
Blow J Julian, Gillespie Peter J
机构信息
Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, DD1 5EH, UK.
出版信息
Nat Rev Cancer. 2008 Oct;8(10):799-806. doi: 10.1038/nrc2500. Epub 2008 Aug 29.
Abstract
Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing is a consequence of oncogene-induced cell proliferation. This misregulation can cause either under- or over-replication of chromosomal DNA, and could explain the genetic instability commonly seen in cancer cells.
摘要
复制许可系统的正确调控可确保染色体DNA在每个细胞分裂周期中精确复制。在多种癌症的肿瘤发生早期，许可蛋白会出现异常表达。在此，我们讨论有关复制许可失调是癌基因诱导的细胞增殖结果的证据。这种失调可能导致染色体DNA的复制不足或过度复制，并可解释癌细胞中常见的遗传不稳定性。
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本文引用的文献
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