防治特定革兰阳性菌感染的有效疫苗的研究进展。
Progress in the development of effective vaccines to prevent selected gram-positive bacterial infections.
机构信息
Division of Infectious Diseases, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA.
出版信息
Am J Med Sci. 2010 Sep;340(3):218-25. doi: 10.1097/MAJ.0b013e3181e939ab.
Abstract
Infections caused by virulent Gram-positive bacteria, such as Staphylococcus aureus, group B streptococci and group A streptococci, remain significant causes of morbidity and mortality despite progress in antimicrobial therapy. Despite significant advances in the understanding of the pathogenesis of infection caused by these organisms, there are only limited strategies to prevent infection. In this article, we review efforts to develop safe and effective vaccines that would prevent infections caused by these 3 pathogens.
摘要
尽管在抗菌治疗方面取得了进展，但化脓性革兰阳性细菌（如金黄色葡萄球菌、B 组链球菌和 A 组链球菌）引起的感染仍然是发病率和死亡率的重要原因。尽管人们对这些病原体引起的感染的发病机制有了显著的认识，但预防感染的策略却很有限。在本文中，我们回顾了开发安全有效的疫苗以预防这 3 种病原体引起的感染的努力。
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