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外周原始神经外胚层肿瘤导致马尾神经综合征并破坏L5椎体。

Peripheral primitive neuroectodermal tumor causing cauda equina syndrome with destruction of L5 vertebra.

作者信息

Dhatt Sarvdeep, Dhillon Mandeep S, Tripathy Sujit K, Goyal Tarun, Jagadeesh V

机构信息

Department of Orthopedics, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh - 160 012, India.

出版信息

Indian J Orthop. 2010 Jul;44(3):339-41. doi: 10.4103/0019-5413.65153.

DOI:10.4103/0019-5413.65153
PMID:20697491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2911938/
Abstract

A 24-year-old male patient presented with cauda equina lesion symptoms. His clinicoradiological examination including X-rays, CT scan and MRI revealed destruction of L(5) vertebral body, pedicle and a mass extending to lateral recess and left intervertebral foramina causing pressure over the thecal sac. A CT guided FNAC was inconclusive. Open biopsy and hemilaminectomy of L(5) vertebra was performed. Histopathology and immunocytochemical analysis revealed it to be primitive neuroectodermal tumor. Patient was given chemotherapy and radiation therapy. His lower limb power improved by grade I post operatively and at 2 years follow-up bowel/bladder recovery was noticed. Patient died after 2.5 years of surgery because of pulmonary metastasis.

摘要

一名24岁男性患者出现马尾神经损伤症状。其临床放射学检查包括X线、CT扫描和MRI,显示L5椎体、椎弓根破坏,有一肿块延伸至侧隐窝和左侧椎间孔,对硬膜囊造成压迫。CT引导下细针穿刺抽吸活检结果不明确。遂行L5椎体开放活检及半椎板切除术。组织病理学和免疫细胞化学分析显示为原始神经外胚层肿瘤。患者接受了化疗和放疗。术后其下肢肌力提高了一级,在2年随访时发现肠道/膀胱功能有所恢复。患者在手术后2.5年因肺转移死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb80/2911938/42f06fd575f0/IJOrtho-44-339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb80/2911938/aa5047413029/IJOrtho-44-339-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb80/2911938/42f06fd575f0/IJOrtho-44-339-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb80/2911938/aa5047413029/IJOrtho-44-339-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb80/2911938/42f06fd575f0/IJOrtho-44-339-g002.jpg

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J Neurooncol. 2009 Apr;92(2):211-7. doi: 10.1007/s11060-008-9744-9. Epub 2008 Dec 3.
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Primary primitive neuroectodermal tumor of the lumbar extradural space.腰椎硬膜外间隙原发性原始神经外胚层肿瘤
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Primitive neuroectodermal tumor of lumbar spine: case report.
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Ewing's sarcoma and primitive neuroectodermal tumour in adults: single-centre experience in The Netherlands.成人尤因肉瘤和原始神经外胚层肿瘤:荷兰的单中心经验
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Peripheral primitive neuroectodermal tumor of the cauda equina in an elderly patient. Case report.老年患者马尾神经外周原始神经外胚层肿瘤。病例报告。
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Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column: report of four cases and a review of the literature.主要起源于脊柱周围的原始神经外胚层肿瘤和骨外尤文肉瘤:4例报告并文献复习
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