Holgate Stephen T
Infection, Inflammation and Immunity Division, Southampton General Hospital, Southampton, UK.
Drug News Perspect. 2010 Jul-Aug;23(6):381-7. doi: 10.1358/dnp.2010.23.6.1437242.
Asthma is a common disorder of the airways which exhibit variable obstruction associated with hyperresponsiveness linked to altered smooth muscle. Although environmental factors are important in the origins and progression of asthma, it is a disorder with high heritability. The identification of ADAM33 (ADAM metallopeptidase domain 33, a disintegrin and metalloproteinase domain 33) as the first novel asthma gene has implications for the mechanisms of airway hyper-responsiveness and airway wall remodeling. This review discusses the molecular regulation of ADAM33, its link to asthma and chronic obstructive pulmonary disease and newly identified functions. These all point to ADAM33 being a key molecule in the development and progression of asthma by contributing to smooth muscle and vascular modeling and remodeling.
哮喘是一种常见的气道疾病，其表现为与平滑肌改变相关的可变阻塞及高反应性。尽管环境因素在哮喘的发病和进展中很重要，但它是一种具有高遗传性的疾病。ADAM33（ADAM金属蛋白酶结构域33，一种解整合素和金属蛋白酶结构域33）作为首个新型哮喘基因的鉴定，对气道高反应性和气道壁重塑机制具有重要意义。本综述讨论了ADAM33的分子调控、其与哮喘和慢性阻塞性肺疾病的联系以及新发现的功能。这些均表明ADAM33通过促进平滑肌和血管的形成及重塑，成为哮喘发生和发展过程中的关键分子。
