Student Research Group of Internal Medicine and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Department of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Int J Mol Sci. 2024 Feb 15;25(4):2318. doi: 10.3390/ijms25042318.
Asthma is a complex chronic respiratory disease characterized by airway hyperresponsiveness, inflammation, and obstruction. Many genes have been identified as associated with asthma but none with such substantial significance as the ADAM33 gene due to its role in airway remodeling and bronchial hyperresponsiveness. This review summarizes the current knowledge on the genetic and functional aspects of ADAM33 in asthma pathogenesis. We highlight its genetic variants associated with asthma susceptibility and severity, as well as the functional effects of ADAM33 on airway remodeling, smooth muscle cell proliferation, and its interplay with environmental factors. Additionally, we discuss the potential clinical implications of ADAM33 as a therapeutic target for asthma management.
哮喘是一种复杂的慢性呼吸系统疾病，其特征是气道高反应性、炎症和阻塞。许多基因已被确定与哮喘有关，但没有一个基因像 ADAM33 基因那样具有如此重要的意义，因为它在气道重塑和支气管高反应性中发挥作用。本综述总结了 ADAM33 在哮喘发病机制中的遗传和功能方面的最新知识。我们强调了与哮喘易感性和严重程度相关的 ADAM33 遗传变异，以及 ADAM33 对气道重塑、平滑肌细胞增殖及其与环境因素相互作用的功能影响。此外，我们还讨论了 ADAM33 作为哮喘管理治疗靶点的潜在临床意义。
