Myers M G, Reeves R A
Division of Cardiology, Sunnybrook Health Science Centre, Toronto, ON, Canada.
Am J Hypertens. 1991 May;4(5 Pt 1):427-31. doi: 10.1093/ajh/4.5.427.
Caffeine produces an acute increase in blood pressure in the research laboratory, but its effect on the ambulatory blood pressure during normal daily activities is unknown. In 25 normotensive, caffeine-naive subjects, daily administration of 400 mg caffeine produced a small increase (+3/+3 mm Hg, P less than .001) in ambulatory daytime blood pressure on the first day, with values returning to baseline by the third day. The initial rise in blood pressure was associated with a fall in heart rate (-3 beats/min, P less than .02). Readings taken the morning following the first day of caffeine ingestion did not show any persistent effect of caffeine on blood pressure. A 400 mg dose of caffeine causes a small increase in daytime ambulatory blood pressure, but tolerance develops with daily caffeine consumption. Infrequent ingestion of caffeine may cause a transient rise in blood pressure which is unlikely to be harmful to an individual but might influence the diagnosis of hypertension in a patient with a borderline elevated blood pressure.
在研究实验室中，咖啡因会使血压急剧升高，但其对日常正常活动期间动态血压的影响尚不清楚。在25名血压正常、未摄入过咖啡因的受试者中，每日服用400毫克咖啡因会使动态日间血压在第一天小幅升高（+3/+3毫米汞柱，P<0.001），到第三天血压值恢复至基线水平。血压最初的升高与心率下降有关（-3次/分钟，P<0.02）。在摄入咖啡因第一天后的早晨进行的测量未显示咖啡因对血压有任何持续影响。400毫克剂量的咖啡因会使日间动态血压小幅升高，但随着每日摄入咖啡因，耐受性会逐渐形成。偶尔摄入咖啡因可能会导致血压短暂升高，这对个体不太可能有害，但可能会影响血压临界升高患者的高血压诊断。
