通过31P磁共振波谱监测NMU诱导的大鼠乳腺肿瘤中他莫昔芬的治疗反应。
Monitoring therapeutic response to tamoxifen in NMU-induced rat mammary tumours by 31P MRS.
作者信息
Baluch S, Midwood C J, Griffiths J R, Stubbs M, Coombes R C
机构信息
CRC Biomedical Magnetic Resonance Research Group, St. George's Hospital Medical School, London, UK.
出版信息
Br J Cancer. 1991 Jun;63(6):901-4. doi: 10.1038/bjc.1991.198.
Tamoxifen injections were given once a week for 4 weeks to 19 rats bearing N-methyl-N-nitrosourea (NMU)-induced mammary carcinomas. NMR spectra were collected on days 2, 7, 14, 21 and 28. Only 42% of the tumours responded to the tamoxifen in that they regressed significantly; another 21% did not change in size and 37% grew significantly. In the ones that did subsequently regress there were significant changes in the NTP/Pi ratio as early as 2 days after treatment, before any detectable change in volume was recorded, and continuing up to 21 days. The significance of these findings and the possible mechanisms underlying the changes are discussed.
对19只患有N-甲基-N-亚硝基脲（NMU）诱导的乳腺癌的大鼠，每周注射一次他莫昔芬，共注射4周。在第2、7、14、21和28天收集核磁共振光谱。只有42%的肿瘤对他莫昔芬有反应，即肿瘤显著消退；另外21%的肿瘤大小没有变化，37%的肿瘤显著生长。在随后消退的肿瘤中，早在治疗后2天，在记录到任何可检测到的体积变化之前，NTP/Pi比值就有显著变化，并持续到21天。讨论了这些发现的意义以及变化背后可能的机制。
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