Gerritsen-van Schieveen Pauline, Royer Bernard
CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Inserm U645, Université de Franche-Comté, Besançon, France.
Therapie. 2010 May-Jun;65(3):201-6. doi: 10.2515/therapie/2010018. Epub 2010 Aug 11.
Pharmacokinetic properties of docetaxel, an anticancer drug, are though to be interesting for therapeutic drug monitoring: high inter- and intra-variability, relationship between exposure and efficacy and especially toxicity. Moreover, the 3-weekly administration, which is the more effective scheme, is also the more toxic. However, neutropenia can be modeled and be efficiently predicted without needing plasma drug concentrations. The level evidence of therapeutic drug monitoring is thus weak regarding the possibility to adapt dose regimen without drug concentrations.
多西他赛是一种抗癌药物，其药代动力学特性对于治疗药物监测而言颇具意义：存在较高的个体间和个体内变异性、暴露量与疗效尤其是毒性之间的关系。此外，每三周给药一次是更有效的方案，但也是毒性更大的方案。然而，中性粒细胞减少症可以建模并有效预测，无需血浆药物浓度。因此，就无需药物浓度来调整给药方案的可能性而言，治疗药物监测的证据水平较弱。
