Schieveen Pauline Gerritsen-van, Hulin Anne, Muret Patrice, Royer Bernard
CHU Besançon, Laboratoire de Pharmacologie Clinique, Hôpital Jean Minjoz, Inserm U645, Université de Franche-Comté, Besançon, France.
Therapie. 2010 May-Jun;65(3):207-12. doi: 10.2515/therapie/2010019. Epub 2010 Aug 11.
Oral etoposide displays high inter- and intra-variability. Convincing relationships were observed between hematological toxicities and exposure of which total etoposide area under the curve seems the more relevant in routine practice. Linear pharmacokinetics, limited sampling strategies and reduction of variability during concentration-controlled studies argue in favor of therapeutic drug monitoring. For these reasons, such practice can be considered as recommended or potentially useful. Further studies using Bayesian approach are nevertheless needed to definitely state regarding the level of evidence therapeutic drug monitoring of oral etoposide.
口服依托泊苷显示出较高的个体间和个体内变异性。观察到血液学毒性与暴露之间存在令人信服的关系，其中在常规实践中，依托泊苷曲线下总面积似乎更具相关性。线性药代动力学、有限采样策略以及浓度控制研究期间变异性的降低都支持治疗药物监测。基于这些原因，这种做法可被视为推荐的或可能有用的。然而，仍需要使用贝叶斯方法进行进一步研究，以明确说明口服依托泊苷治疗药物监测的证据水平。
