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癌症化疗中药物给药时间安排的重要性：以依托泊苷为例。

The importance of drug scheduling in cancer chemotherapy: etoposide as an example.

作者信息

Hande K R

机构信息

Vanderbilt University School of Medicine, Nashville VA Medical Center, TN 37232, USA.

出版信息

Stem Cells. 1996 Jan;14(1):18-24. doi: 10.1002/stem.140018.

DOI:10.1002/stem.140018
PMID:8820946
Abstract

Etoposide is a drug whose antineoplastic activity is dependent on the schedule of drug administration. This article reviews the rationale for a prolonged schedule of etoposide administration and the therapeutic results of use of such a schedule in the treatment of cancer. The pharmacology of etoposide is also reviewed, with particular attention paid to the pharmacokinetics of oral etoposide and etoposide plasma concentrations associated with cytotoxicity.

摘要

依托泊苷是一种抗肿瘤活性取决于给药方案的药物。本文综述了延长依托泊苷给药方案的理论依据以及使用该方案治疗癌症的疗效。同时还综述了依托泊苷的药理学，特别关注口服依托泊苷的药代动力学以及与细胞毒性相关的依托泊苷血浆浓度。

相似文献

1
The importance of drug scheduling in cancer chemotherapy: etoposide as an example.癌症化疗中药物给药时间安排的重要性：以依托泊苷为例。
Stem Cells. 1996 Jan;14(1):18-24. doi: 10.1002/stem.140018.
2
The Importance of Drug Scheduling in Cancer Chemotherapy: Etoposide as an Example.药物给药方案在癌症化疗中的重要性：以依托泊苷为例。
Oncologist. 1996;1(4):234-239.
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[Etoposide in the treatment of small-cell lung cancer].[依托泊苷治疗小细胞肺癌]
Gan To Kagaku Ryoho. 1996 Dec;23(14):1920-4.
4
Review of current clinical experience with prolonged (oral) etoposide in cancer treatment.
Anticancer Res. 1995 Sep-Oct;15(5B):2319-30.
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[Combined chemotherapy after prolonged oral etoposide maintenance therapy in patients with small-cell lung cancer].
Orv Hetil. 2000 Sep 10;141(37):2035-8.
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Etoposide: seeking the best dose and schedule.
Semin Oncol. 1992 Dec;19(6 Suppl 14):59-63.
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[Level of evidence for therapeutic drug monitoring for etoposide after oral administration].[口服给药后依托泊苷治疗药物监测的证据级别]
Therapie. 2010 May-Jun;65(3):207-12. doi: 10.2515/therapie/2010019. Epub 2010 Aug 11.
8
Therapeutic drug monitoring of 21-day oral etoposide in patients with advanced non-small cell lung cancer.晚期非小细胞肺癌患者口服依托泊苷21天的治疗药物监测
Clin Cancer Res. 1998 Jul;4(7):1705-10.
9
[Effectiveness of prolonged oral administration of low-dose etoposide in a case of malignant lymphoma in the mesenterium].
Gan To Kagaku Ryoho. 2002 Jun;29(6):959-62.
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[Prolonged oral etoposide therapy in advanced stage lung cancer].[晚期肺癌的长期口服依托泊苷治疗]
Orv Hetil. 1997 Jul 13;138(28):1791-5.

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