Purdue University, Department of Speech, Language, and Hearing Sciences, 1353 Heavilon Hall, 500 Oval Drive, West Lafayette, IN 47907-2038, USA.
J Speech Lang Hear Res. 2011 Feb;54(1):19-32. doi: 10.1044/1092-4388(2010/09-0079). Epub 2010 Aug 10.
This study examined the effect of Parkinson's disease (PD) on the intonational marking of final and nonfinal syntactic boundaries and investigated whether the effect of PD on intonation was sex specific.
Eight women and 8 men with PD and 16 age- and sex-matched control participants read a passage at comfortable pitch, rate, and loudness. Nuclear tones from final and nonfinal syntactic boundaries in clauses and lists were extracted. Measures of fundamental frequency (F0) were made on each tone contour.
Individuals with PD demonstrated impaired differentiation of syntactic boundary finality/nonfinality with contour direction. They produced a lower proportion of falling contours in final boundaries and a higher proportion of falling contours in nonfinal boundaries than did control participants. Although not mediated by syntax, the effect of PD on F0 standard deviation (F0 SD) and pitch range in semitones (PRST) was sex specific. Women with PD produced greater F0 SD and PRST than did men with PD and women without PD. Men with PD produced lower PRST than did men without PD.
Impaired intonational marking of syntactic boundaries likely contributes to dysprosody and reduced communicative effectiveness in PD. The effect of PD on intonation was sex specific. The results are not fully explained by PD-related motor execution impairments.
本研究考察了帕金森病（PD）对最终和非最终句法边界的语调标记的影响，并探讨了 PD 对语调的影响是否具有性别特异性。
8 名女性和 8 名男性 PD 患者和 16 名年龄和性别匹配的对照参与者以舒适的音高、速率和响度朗读一段话。从句和列表中的最终和非最终句法边界的核音被提取出来。对每个语调轮廓进行了基频（F0）的测量。
PD 患者在语调边界的终结性/非终结性区分方面表现出了受损。他们在最终边界产生的下降语调比例较低，而非最终边界的下降语调比例较高，这与对照参与者不同。尽管不受句法影响，但 PD 对 F0 标准差（F0 SD）和半音音高范围（PRST）的影响具有性别特异性。PD 女性的 F0 SD 和 PRST 大于 PD 男性和无 PD 女性。PD 男性的 PRST 低于无 PD 男性。
句法边界语调标记受损可能导致 PD 患者的语音障碍和沟通效果降低。PD 对语调的影响具有性别特异性。这些结果不能完全用与 PD 相关的运动执行障碍来解释。
