Jiménez-Jiménez F J, Gamboa J, Nieto A, Guerrero J, Orti-Pareja M, Molina J A, García-Albea E, Cobeta I
Departments of Neurology, Hospital Universitario 'Principe de Asturias', Alcalá de HenaresMadrid Spain.
Parkinsonism Relat Disord. 1997 Apr;3(2):111-6. doi: 10.1016/s1353-8020(97)00007-2.
To quantify several acoustic features of the voice in patients with Parkinson's disease (PD) not treated with dopaminergic drugs, 22 PD patients and 28 age and sex-matched controls were studied. The Computerized Speech Lab 4300 program (Kay Elemetrics) was used. Two seconds of a sustained /a/ and a sentence were captured with a microphone and laryngograph equipment. Measures included fundamental frequency (F(0)), frequency perturbation (jitter), intensity perturbation (shimmer), and harmonic/noise ratio (HIN) of the vowel /a/, and frequency and intensity variability of a sentence, phonational range, dynamic range at the natural frequency, maximum phonational time and s z ratio. All subjects underwent indirect laryngoscopy and/or laryngeal fibroscopy. When compared to controls, PD patients showed higher jitter and shimmer, lower H N ratio, and lower frequency variability of the sentence in the microphonic signal and reported a higher frequency of presence of low voice intensity, monopitch, harshness, voice arrests, and tremor.
为了量化未接受多巴胺能药物治疗的帕金森病（PD）患者声音的几种声学特征，对22例PD患者以及28例年龄和性别匹配的对照者进行了研究。使用了计算机语音实验室4300程序（凯伊电子仪器公司）。用麦克风和喉描记设备采集两秒的持续发/a/音和一个句子。测量指标包括元音/a/的基频（F(0)）、频率微扰（抖动）、强度微扰（闪烁）和谐波/噪声比（HIN），以及一个句子的频率和强度变异性、发声范围、自然频率下的动态范围、最大发声时间和s/z比值。所有受试者均接受了间接喉镜检查和/或喉纤维镜检查。与对照组相比，PD患者表现出更高的抖动和闪烁、更低的H/N比值，以及在麦克风信号中句子的频率变异性更低，并且报告低声强、单音调、粗糙声、声音停顿和震颤出现的频率更高。
