Department of Medicine, New York Medical College/Westchester Medical Center, Valhalla, NY 10595, USA.
Cardiol Rev. 2010 Sep-Oct;18(5):251-7. doi: 10.1097/CRD.0b013e3181e84673.
Cardiovascular disease remains the leading cause of death in most of the developed world despite advances in both prevention and treatment. At the same time, the incidence rates of cardiovascular disease differ greatly between the genders, with men more likely than women to manifest ischemic heart disease. This observation has prompted new research initiatives to explain the discrepancy in heart disease prevalence and incidence between the sexes. Whether androgens affect cardiovascular disease adversely remains a contentious issue, with some data pointing to a deleterious effect of androgens on lipid profiles, and other studies revealing androgens' possible benefits on cardiovascular function. This review will examine the relationship between the endogenous production of androgen as well as the exogenous replacement of testosterone in men and the possible links to cardiovascular disease. The role of testosterone in male cardiovascular health is not completely understood, and additional studies are needed to explain its effect on atherosclerosis and its complications.
尽管在预防和治疗方面都取得了进步，但心血管疾病仍然是大多数发达国家的主要死因。与此同时，心血管疾病的发病率在性别之间存在很大差异，男性比女性更容易出现缺血性心脏病。这一观察结果促使新的研究计划来解释男女之间心脏病患病率和发病率的差异。雄激素是否对心血管疾病有不利影响仍然是一个有争议的问题，一些数据表明雄激素对脂质谱有有害影响，而其他研究则揭示了雄激素对心血管功能的可能益处。这篇综述将探讨男性内源性雄激素的产生以及外源性睾酮替代与心血管疾病之间的可能联系。睾酮在男性心血管健康中的作用尚不完全清楚，需要进一步的研究来解释其对动脉粥样硬化及其并发症的影响。
