雄激素受体基因变异的性别特异性与冠状动脉疾病风险
Gender Specificity of a Genetic Variant of Androgen Receptor and Risk of Coronary Artery Disease.
作者信息
Agiannitopoulos Konstantinos, Bakalgianni Angeliki, Marouli Eirini, Zormpa Ioanna, Manginas Athanasios, Papamenzelopoulos Spyros, Lamnissou Klea
机构信息
Department of Genetics and Biotechnology, Faculty of Biology, University of Athens, Athens, Greece.
First Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
出版信息
J Clin Lab Anal. 2016 May;30(3):204-7. doi: 10.1002/jcla.21837. Epub 2015 Feb 25.
BACKGROUND
Androgens are known to influence the risk of developing cardiovascular diseases. This study aims at investigating the possible association between G1733A polymorphism in the coding region of androgen receptor (AR) gene and premature coronary artery disease (CAD).
METHODS
A total of 460 Greek subjects were investigated for the G1733A polymorphism. The patient group consisted of 250 CAD individuals, aged less than 58 years, while 210 healthy individuals served as controls. Genotyping was performed using the PCR-RFLP method.
RESULTS
Significant differences in genotype distribution (P = 0.0067) and allele frequencies (P = 0.0060) have been observed between patients and controls in the women's subgroup. Conversely, the genotype/allele frequencies were similar between patients and controls in the subgroup of men.
CONCLUSION
We may conclude that the G1733A polymorphism of AR gene could be a useful genetic marker for the assessment of a woman's risk for CAD in our Caucasian Greek population.
背景
已知雄激素会影响患心血管疾病的风险。本研究旨在调查雄激素受体（AR）基因编码区的G1733A多态性与早发性冠状动脉疾病（CAD）之间可能存在的关联。
方法
共对460名希腊受试者进行了G1733A多态性检测。患者组由250名年龄小于58岁的CAD患者组成，210名健康个体作为对照。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法进行基因分型。
结果
在女性亚组中，患者与对照之间在基因型分布（P = 0.0067）和等位基因频率（P = 0.0060）方面存在显著差异。相反，在男性亚组中，患者与对照之间的基因型/等位基因频率相似。
结论
我们可以得出结论，在我们的希腊白种人群中，AR基因的G1733A多态性可能是评估女性CAD风险的一个有用的遗传标志物。
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