Infectious disease ward, Razi Hospital, Ahvaz Joundishapour University of Medical Sciences, Ahvaz, Iran.
J Infect Public Health. 2009;2(2):96-9. doi: 10.1016/j.jiph.2009.04.001. Epub 2009 May 28.
Several studies suggested that Chlamydia pneumoniae (CP) infection may be a risk factor for cerebrovascular disease. Since these studies have reported controversial results, we performed this study to identify whether Cp-immunoglobulin was associated with atherothrombotic cerebrovascular infarction (ACI) in Iranian patients.
Forty-five patients admitted with ACI, and 45 control without ACI were enrolled in this case-control study. Using an enzyme-linked immunosorbed assay kit (ELISA), the presence of CP-immunoglobulin (CP-IgG) in studied patient's sera was determined.
The seroprevalence of CP-IgG was 35(77.7%) in the ACI group (mean age=73.3 years) and 29(64.4%) in the control group (mean age=70.1 years) (P>0.05). There was no difference in sex, age, hypertension, smoking, hyperlipidemia, diabetes and obesity between cases and control groups (P>0.05). No association was observed between CP seropositivity and ACI [OR: 1.95 (95% CI, 0.081-2.03), P=0.16].
Our finding suggests that there is no association between ACI and positive CP-IgG in Iranian patients.
几项研究表明，肺炎衣原体（CP）感染可能是脑血管病的危险因素。由于这些研究的结果存在争议，我们进行了这项研究，以确定 CP 免疫球蛋白是否与伊朗患者的动脉粥样硬化血栓性脑梗死（ACI）有关。
本病例对照研究纳入了 45 例 ACI 患者和 45 例无 ACI 的对照患者。使用酶联免疫吸附试验试剂盒（ELISA），检测患者血清中 CP 免疫球蛋白（CP-IgG）的存在。
ACI 组的 CP-IgG 血清阳性率为 35（77.7%）（平均年龄=73.3 岁），对照组为 29（64.4%）（平均年龄=70.1 岁）（P>0.05）。病例组和对照组在性别、年龄、高血压、吸烟、高血脂、糖尿病和肥胖方面无差异（P>0.05）。CP 血清阳性与 ACI 之间无相关性[比值比：1.95（95%置信区间，0.081-2.03），P=0.16]。
我们的研究结果表明，在伊朗患者中，ACI 与 CP-IgG 阳性之间没有关联。
