Department of Neurology, Riga Stradins University, Riga, Latvia.
Medicina (Kaunas). 2011;47(12):657-60.
Serological evidence of infection with Chlamydia pneumoniae has been associated with cardiovascular diseases, but the relationship with stroke and its risk factors remains not completely understood. The aim of this study was to determine whether serological evidence of infection with Chlamydia pneumoniae was associated with the risk of ischemic stroke and any of investigated stroke subtypes.
Confirmed stroke cases (n=102) were compared with gender- and age-matched control patients (n=48). The patients with stroke were divided into 3 groups according to the TOAST criteria: atherothrombotic (n=36), cardioembolic (n=47), and of undetermined etiology (n=19). Plasma levels of IgG antibodies to Chlamydia pneumoniae were measured by enzyme-linked immunosorbent assay.
There was a significant association between seropositivity to Chlamydia pneumoniae and stroke. Anti-Chlamydia pneumoniae IgG antibodies were detected in 64 case patients (62.7%) and 17 control patients (35.4%) (χ(2)=9.8; df=1; P=0.002). IgG seropositivity to Chlamydia pneumoniae was linked to all the analyzed etiological subtypes of stroke.
This study showed that IgG seropositivity to Chlamydia pneumoniae was associated with stroke and all the analyzed etiological subtypes of stroke.
肺炎衣原体感染的血清学证据与心血管疾病有关，但与中风及其危险因素的关系仍不完全清楚。本研究旨在确定肺炎衣原体感染的血清学证据是否与缺血性中风的风险以及任何已调查的中风亚型有关。
将确诊的中风病例（n=102）与性别和年龄匹配的对照患者（n=48）进行比较。根据 TOAST 标准，将中风患者分为 3 组：动脉粥样硬化血栓形成（n=36）、心源性栓塞（n=47）和病因不明（n=19）。通过酶联免疫吸附试验测量肺炎衣原体 IgG 抗体的血浆水平。
肺炎衣原体血清阳性与中风之间存在显著关联。在 64 例病例患者（62.7%）和 17 例对照患者（35.4%）中检测到抗肺炎衣原体 IgG 抗体（χ(2)=9.8；df=1；P=0.002）。肺炎衣原体 IgG 血清阳性与所有分析的中风病因亚型有关。
本研究表明，肺炎衣原体 IgG 血清阳性与中风和所有分析的中风病因亚型有关。
