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Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma.

作者信息

Davenport E L, Zeisig A, Aronson L I, Moore H E, Hockley S, Gonzalez D, Smith E M, Powers M V, Sharp S Y, Workman P, Morgan G J, Davies F E

出版信息

Leukemia. 2010 Oct;24(10):1804-7. doi: 10.1038/leu.2010.168. Epub 2010 Aug 12.

DOI:10.1038/leu.2010.168
PMID:20703255
Abstract
摘要

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Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma.靶向热休克蛋白72可增强热休克蛋白90抑制剂诱导的骨髓瘤细胞凋亡。
Leukemia. 2010 Oct;24(10):1804-7. doi: 10.1038/leu.2010.168. Epub 2010 Aug 12.
2
An activated JAK/STAT3 pathway and CD45 expression are associated with sensitivity to Hsp90 inhibitors in multiple myeloma.JAK/STAT3 通路的激活和 CD45 的表达与多发性骨髓瘤对热休克蛋白 90 抑制剂的敏感性相关。
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3
Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis.对热休克蛋白70（HSC70）和热休克蛋白72（HSP72）的双重靶向作用可抑制热休克蛋白90（HSP90）的功能并诱导肿瘤特异性凋亡。
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4
Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.蛋白激酶 CK2 通过调控未折叠蛋白反应保护多发性骨髓瘤细胞免受内质网应激诱导的凋亡和热休克蛋白 90 抑制的细胞毒性作用。
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Combination mammalian target of rapamycin inhibitor rapamycin and HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin has synergistic activity in multiple myeloma.雷帕霉素的哺乳动物靶点抑制剂雷帕霉素与热休克蛋白90抑制剂17-烯丙基氨基-17-去甲氧基格尔德霉素联合使用在多发性骨髓瘤中具有协同活性。
Clin Cancer Res. 2006 Nov 15;12(22):6826-35. doi: 10.1158/1078-0432.CCR-06-1331.
6
Abrogation of heat shock protein 70 induction as a strategy to increase antileukemia activity of heat shock protein 90 inhibitor 17-allylamino-demethoxy geldanamycin.废除热休克蛋白70的诱导作为一种增加热休克蛋白90抑制剂17-烯丙基氨基-去甲氧基格尔德霉素抗白血病活性的策略。
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17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.17-AAG和17-DMAG通过下调野生型B-Raf表达的葡萄膜黑色素瘤细胞系中的B-Raf来抑制细胞增殖。
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2348-56. doi: 10.1167/iovs.07-1305. Epub 2008 Feb 15.
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Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis.自噬抑制使多发性骨髓瘤细胞对 17-二甲基氨基乙基氨基-17-去甲氧基格尔德霉素诱导的细胞凋亡敏感。
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9
ATP analog enhances the actions of a heat shock protein 90 inhibitor in multiple myeloma cells.三磷酸核苷类似物增强热休克蛋白 90 抑制剂在多发性骨髓瘤细胞中的作用。
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Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.17-烯丙基氨基-17-去甲氧基格尔德霉素对霍奇金淋巴瘤细胞中热休克蛋白90功能的抑制作用可下调Akt激酶、使细胞外信号调节激酶去磷酸化，并诱导细胞周期停滞和细胞死亡。
Clin Cancer Res. 2006 Jan 15;12(2):584-90. doi: 10.1158/1078-0432.CCR-05-1194.

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Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin).辣椒素结合 Hsp90 的 N 端，诱导 Hsp70 的溶酶体降解，并增强 17-AAG（坦那霉素）的抗肿瘤作用。
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The Mitochondrial Chaperone TRAP1 as a Candidate Target of Oncotherapy.
线粒体伴侣蛋白TRAP1作为肿瘤治疗的候选靶点
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Heat Shock Proteins Are Essential Components in Transformation and Tumor Progression: Cancer Cell Intrinsic Pathways and Beyond.热休克蛋白是转化和肿瘤进展中的重要组成部分：癌细胞内在途径及其他。
Int J Mol Sci. 2019 Sep 11;20(18):4507. doi: 10.3390/ijms20184507.
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