肝细胞生长因子是强直性脊柱炎成骨过度增生和骨质疏松的一个潜在生物标志物。
Hepatocyte growth factor is a potential biomarker for osteoproliferation and osteoporosis in ankylosing spondylitis.
机构信息
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at the University of Gothenburg, Guldhedsgatan 10A, S-413 46, Gothenburg, Sweden.
Department of Public Health and Clinical Medicine, Rheumatology, Umeå University, Umeå, Sweden.
出版信息
Osteoporos Int. 2019 Feb;30(2):441-449. doi: 10.1007/s00198-018-4721-4. Epub 2018 Oct 10.
UNLABELLED
We explored relations between serum hepatocyte growth factor (HGF), disease activity, osteoproliferation, and bone mineral density (BMD) in ankylosing spondylitis (AS), in comparison with healthy controls. HGF was increased especially in male AS patients and smokers and associated with both lower BMD and more chronic radiographic changes in the spine.
INTRODUCTION
Ankylosing spondylitis (AS) is characterized by both osteoproliferation and increased bone loss. Biomarkers are requested to predict the processes. The aims of this study were to compare serum levels of hepatocyte growth factor (HGF), matrix metalloproteinase-3 (MMP-3), and vascular endothelial growth factor (VEGF) in AS patients with healthy controls (HC) and to explore the associations with disease activity, osteoproliferation, and bone mineral density (BMD).
METHODS
Serum from AS patients (modified NY-criteria) and HC was analyzed for HGF, MMP-3, and VEGF with ELISA. Disease activity parameters were collected. Osteoproliferation was assessed with modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) and BMD was measured in femoral neck.
RESULTS
Totally, 204 AS patients and 80 sex and age matched HC were included. Serum HGF was higher in the AS patients compared with the HC, whereas serum MMP-3 and VEGF were not. Serum HGF was also higher in smokers and in the male AS patients positively correlated with age, BASMI, and mSASSS, and negatively correlated with BMD. The biomarkers were all positively associated with ESR, CRP, and WBC. In multiple linear regression analysis serum HGF remained associated with higher mSASSS and lower BMD, after adjusting for age, sex, CRP, smoking, and body mass index.
CONCLUSIONS
Serum HGF was increased in male AS patients and associated with higher mSASSS and lower BMD. In addition, serum HGF was positively associated with risk factors for osteoproliferation such as age, CRP and smoking. HGF could be a potential biomarker of importance for the bone metabolism in AS.
TRIAL REGISTRATION
NCT00858819.
目的
探讨血清肝细胞生长因子（HGF）与疾病活动度、成骨增殖及骨密度（BMD）在强直性脊柱炎（AS）中的关系，并与健康对照组（HC）进行比较。结果：共纳入 204 例 AS 患者和 80 例性别和年龄匹配的 HC。与 HC 相比，AS 患者的血清 HGF 水平较高，而血清 MMP-3 和 VEGF 水平则无差异。吸烟和男性 AS 患者的血清 HGF 水平也较高，与年龄、BASMI 和 mSASSS 呈正相关，与 BMD 呈负相关。这些生物标志物均与 ESR、CRP 和 WBC 呈正相关。在多元线性回归分析中，调整年龄、性别、CRP、吸烟和体重指数后，血清 HGF 仍与较高的 mSASSS 和较低的 BMD 相关。结论：男性 AS 患者血清 HGF 升高，与较高的 mSASSS 和较低的 BMD 相关。此外，血清 HGF 与 CRP 和吸烟等成骨增殖的危险因素呈正相关。HGF 可能是 AS 骨代谢的一个潜在的重要生物标志物。
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