中国厚壳树叶的细胞毒素类黄酮。

Cytotoxic flavonoids from the leaves of Cryptocarya chinensis.

机构信息

Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.

出版信息

J Nat Prod. 2010 Sep 24;73(9):1470-5. doi: 10.1021/np100014j.

DOI:10.1021/np100014j

PMID:20704331

Abstract

Bioassay-guided fractionation led to the isolation of six new tetrahydroflavanones, cryptochinones A-F (1-6), from the neutral CHCl(3) fraction of Cryptocarya chinensis leaves, together with 14 known compounds (7-20). The structures of these new compounds were determined through spectroscopic analyses, including 2D-NMR, MS, CD, and X-ray crystallographic analysis. Among the isolates, infectocaryone (7) showed cytotoxic activities with IC(50) values of 11.0 and 3.7 μM against NCI-H460 and SF-268 cell lines, respectively, and cryptocaryanone A (9) showed cytotoxic activities with IC(50) values of 5.1, 4.3, and 5.0 μM against MCF-7, NCI-H460, and SF-268 cell lines, respectively.

摘要

基于生物活性导向的分离方法，从Cryptocarya chinensis 叶的中性 CHCl(3)部分中分离得到了六种新的四氢黄酮醇，即 cryptochinones A-F（1-6），同时还分离得到了 14 种已知化合物（7-20）。这些新化合物的结构通过光谱分析确定，包括 2D-NMR、MS、CD 和 X 射线晶体学分析。在分离得到的化合物中，infectocaryone（7）对 NCI-H460 和 SF-268 细胞系的细胞毒活性的 IC(50)值分别为 11.0 和 3.7 μM，cryptocaryanone A（9）对 MCF-7、NCI-H460 和 SF-268 细胞系的细胞毒活性的 IC(50)值分别为 5.1、4.3 和 5.0 μM。