Li Lu-Jun, Zhang Yue, Zhang Peng, Pi Hui-Fang, Ruan Han-Li, Wu Ji-Zhou
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmaceutical Sciences, Huazhong University of Science and Technology, Wuhan, China.
J Asian Nat Prod Res. 2011 Apr;13(4):341-5. doi: 10.1080/10286020.2011.557021.
Two new 5,8-quinoflavans were isolated from the leaf of Ilex centrochinensis, and their structures were elucidated as (2R)-7,3',4'-trimethoxy-5,8-quinoflavan and (2S)-7-methoxy-4'-hydroxy-5,8-quinoflavan on the basis of spectroscopic methods, especially 1D and 2D NMR, CD, and mass spectral analyses. Both of them exhibited weak cytotoxic activity against HuH7 cell lines and no cytotoxic activity against CaCO-2 cell lines.
从中华冬青叶中分离出两种新的5,8-喹诺黄酮，通过光谱方法，尤其是一维和二维核磁共振、圆二色光谱和质谱分析，确定它们的结构分别为(2R)-7,3',4'-三甲氧基-5,8-喹诺黄酮和(2S)-7-甲氧基-4'-羟基-5,8-喹诺黄酮。它们对HuH7细胞系均表现出较弱的细胞毒活性，对CaCO-2细胞系无细胞毒活性。
