State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
J Org Chem. 2010 Aug 20;75(16):5754-6. doi: 10.1021/jo101059e.
A facile stereoselective total synthesis of cleistenolide (1) from the natural chiral template d-arabinose has been achieved in eight steps and 49% overall yield, employing key steps including Wittig olefination, selective 1,3-trans-acetal formation, and modified Yamaguchi esterification.
从天然手性模板 D-阿拉伯糖出发，经八步反应以 49%的总收率实现了 cleistenolide（1）的立体选择性全合成，关键步骤包括 Wittig 烯烃化、选择性 1,3-反式缩醛形成以及改良的 Yamaguchi 酯化反应。
