Li Chen, Lee Dongho, Graf Tyler N, Phifer Sharnelle S, Nakanishi Yuka, Riswan Soedarsono, Setyowati Fransisca M, Saribi Achmad M, Soejarto Djaja D, Farnsworth Norman R, Falkinham Joseph O, Kroll David J, Kinghorn A Douglas, Wani Mansukh C, Oberlies Nicholas H
Natural Products Laboratory, Research Triangle Institute, P.O. Box 12194, Research Triangle Park, North Carolina 27709-2194, USA.
J Nat Prod. 2009 Nov;72(11):1949-53. doi: 10.1021/np900572g.
Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three ent-kaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.
对光滑银钩花茎皮进行生物活性导向的分离，得到了9种化合物，包括3种对映-贝壳杉烷类化合物（1-3）、5种多炔酸/酯（4-8）和1种阿朴啡生物碱，鹅掌楸碱（9）。通过光谱数据解析确定了6种新化合物（1-3、5、7和8）的结构。对所有化合物针对一组癌细胞系和一系列微生物的抑制活性进行了评估。
