Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China.
Biochem J. 2010 Sep 1;430(2):191-8. doi: 10.1042/BJ20100427.
Tight regulation of TGF-beta (transforming growth factor-beta) superfamily signalling is important for normal cellular functions and tissue homoeostasis. Since TGF-beta superfamily signalling pathways are activated by a short phosphorylation cascade, from receptor phosphorylation to subsequent phosphorylation and activation of downstream signal transducer R-Smads (receptor-activated Smads), reversible phosphorylation serves as a critical step to assure proper TGF-beta signalling. The present article will review the current progress on the understanding of dynamic phosphorylation in TGF-beta signalling and the essential role of protein phosphatases in this process.
TGF-β(转化生长因子-β)超家族信号的严格调控对于正常的细胞功能和组织平衡至关重要。由于 TGF-β 超家族信号通路是通过短的磷酸化级联激活的,从受体磷酸化到下游信号转导器 R-Smads(受体激活的 Smads)的后续磷酸化和激活,可逆磷酸化是确保适当 TGF-β 信号的关键步骤。本文将综述 TGF-β 信号中动态磷酸化的理解的最新进展,以及蛋白磷酸酶在这一过程中的重要作用。