Wang Shuhua, Qi Yanli, Zhang Junyi, Zhang Qingfu, Li Haiying, Qiu Xueshan
Department of Pathology, College of Basic Medical Sciences, China Medical University, Shenyang 110001, China.
Zhongguo Fei Ai Za Zhi. 2010 Aug;13(8):777-80. doi: 10.3779/j.issn.1009-3419.2010.08.05.
It has been proven that MTA2 was expressed in many tumor cell lines and was correlated with tumor invasion and metastasis. The aim of this study is to investigate the expression of MTA2 protein in non-small cell lung cancer (NSCLC) and to explore the relationship between the expression of MTA2 and the pathological features.
The expression of MTA2 protein in 110 cases of NSCLC and 34 cases corresponding lung tissues was detected with immunohistochemistry method. The relationship between the expression of MTA2 and the pathological features in NSCLC was analyzed statistically.
There was no expression of MTA2 protein in cancer collateral branch trachea epithelial and alveolar epithelial, but there was some expression in partial NSCLC. The positive rate of MTA2 was 58.18% (64/110) in 110 NSCLC cases. The expression of MTA2 had negative correlation with differentiation degree of NSCLC but had positive correlation with clinical stage and lymph node metastasis (P<0.05), moreover, it had no obvious correlation with age, gender and pathological type (P>0.05).
There was some expression of MTA2 in partial NSCLC and it was correlated with differentiation degree, clinical stage and lymph node metastasis. The results show that the occurrence and development of lung cancer may be related with MTA2. MTA2 may act as a new symbol and target in the treatment of lung cancer.
已证实MTA2在多种肿瘤细胞系中表达，并与肿瘤侵袭和转移相关。本研究旨在探讨MTA2蛋白在非小细胞肺癌（NSCLC）中的表达情况，并探讨MTA2表达与病理特征之间的关系。
采用免疫组织化学方法检测110例NSCLC及34例相应肺组织中MTA2蛋白的表达。对NSCLC中MTA2表达与病理特征的关系进行统计学分析。
癌旁支气管上皮和肺泡上皮中无MTA2蛋白表达，但部分NSCLC中有一定表达。110例NSCLC中MTA2阳性率为58.18%（64/110）。MTA2的表达与NSCLC的分化程度呈负相关，与临床分期和淋巴结转移呈正相关（P<0.05），此外，与年龄、性别和病理类型无明显相关性（P>0.05）。
部分NSCLC中有MTA2的一定表达，且与分化程度、临床分期和淋巴结转移相关。结果表明肺癌的发生发展可能与MTA2有关。MTA2可能成为肺癌治疗的新标志物和靶点。
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