Otto-von-Guericke-University Magdeburg, Clinic for Child and Adolescent Psychiatry, Leipziger Str. 44, 39120 Magdeburg, Germany.
Int J Psychophysiol. 2011 Jan;79(1):25-31. doi: 10.1016/j.ijpsycho.2010.08.002. Epub 2010 Aug 10.
Evoked gamma-band responses (GBRs) were shown to be involved in different aspects of human cognition and behavior. They have been linked to the integration and processing of incoming information leading to an adequate behavioral outcome. Consequently, altered evoked GBRs have been associated with impaired cognitive and behavioral states present in a variety of psychiatric disorders. However, to the best of our knowledge, there are no reports directly comparing evoked GBRs of different clinical groups in the same experimental setting. Thus, the purpose of the present study was to shed light on the question, whether evoked GBRs, as a kind of a neurophysiological biomarker of pathological states, might serve for characterization and distinguishing of groups suffering from diverse psychiatric disorders. We measured EEG during a passive auditory oddball-paradigm. Participants were patients diagnosed with schizophrenia, mood disorder, and personality disorders as well as a fourth group consisting of healthy participants. Our results indicate that evoked GBRs significantly differed from healthy participants only in schizophrenic patients whereas no difference could be observed for the other clinical groups. Our findings support the notion that early evoked GBRs could be indeed a trait variable of schizophrenia and are not a general marker of pathological brain states.
诱发伽马频带反应（GBRs）被证明参与了人类认知和行为的不同方面。它们与传入信息的整合和处理有关，从而导致适当的行为结果。因此，改变的诱发 GBRs 与各种精神障碍中存在的认知和行为障碍状态有关。然而，据我们所知，在相同的实验环境中，没有直接比较不同临床组的诱发 GBRs 的报告。因此，本研究的目的是探讨一个问题，即作为病理状态的神经生理学生物标志物的诱发 GBRs 是否可以用于表征和区分患有不同精神障碍的组。我们在被动听觉Oddball 范式期间测量了 EEG。参与者是被诊断患有精神分裂症、情绪障碍和人格障碍的患者，以及由健康参与者组成的第四组。我们的结果表明，只有精神分裂症患者的诱发 GBRs 与健康参与者有显著差异，而其他临床组则没有差异。我们的发现支持这样一种观点，即早期的诱发 GBRs 确实可能是精神分裂症的一种特质变量，而不是病理性大脑状态的一般标志物。
