Parker L U, Bergfeld W F
Department of Dermatology, Cleveland Clinic Foundation, Ohio 44195.
Cleve Clin J Med. 1991 Jan-Feb;58(1):43-6. doi: 10.3949/ccjm.58.1.43.
Topical testosterone is recognized as a standard treatment for vulvar lichen sclerosus et atrophicus. Systemic androgenic side effects of this medication are widely believed to be uncommon and mild. A case is reported of severe hirsutism with other signs of virilization and markedly elevated serum testosterone levels secondary to use of topical testosterone propionate for vulvar lichen sclerosus et atrophicus. Caution is necessary in the use of topical testosterone, with close monitoring for signs of virilization. Alternative treatments for this condition, such as intralesional corticosteroids or topical progesterone, are recommended to avoid the risk of androgenic side effects.
外用睾酮被认为是外阴硬化性苔藓及萎缩性苔藓的标准治疗方法。人们普遍认为这种药物的全身性雄激素副作用并不常见且较为轻微。本文报告了一例因使用外用丙酸睾酮治疗外阴硬化性苔藓及萎缩性苔藓而导致严重多毛症及其他男性化体征，且血清睾酮水平显著升高的病例。使用外用睾酮时必须谨慎，并密切监测男性化体征。建议采用其他治疗方法，如病灶内注射皮质类固醇或外用孕激素，以避免雄激素副作用的风险。
