Sideri M, Origoni M, Spinaci L, Ferrari A
1st Department of Obstetrics and Gynecology, L. Mangiagalli Institute, Milan, Italy.
Int J Gynaecol Obstet. 1994 Jul;46(1):53-6. doi: 10.1016/0020-7292(94)90309-3.
Comparison between 2% testosterone propionate and petrolatum ointment in the treatment of vulvar lichen sclerosus in a randomized, double-blind, controlled clinical study.
Fifty-eight consecutive patients with histologically confirmed vulvar lichen sclerosus were enrolled. They underwent a 1-year period of topical treatment with either medication, with clinical evaluations of symptoms and gross appearance at 2-month intervals, followed by histological evaluation at the end of the treatment period. Statistical analysis was performed according to the chi-squared test and the Student-Newman-Keuls test.
A substantial improvement in symptoms was achieved in 20 (66.6%) patients in the testosterone group and in 21 (75%) patients in the placebo group. No statistical differences were observed between the two groups. Gross changes were observed in a few cases and no case demonstrated histologic modifications.
Petrolatum ointment is as effective as 2% testosterone in the treatment of vulvar lichen sclerosus.
在一项随机、双盲、对照临床研究中，比较2%丙酸睾酮与凡士林软膏治疗外阴硬化性苔藓的效果。
纳入58例经组织学确诊的外阴硬化性苔藓患者。她们接受为期1年的两种药物之一的局部治疗，每2个月进行症状和外观的临床评估，治疗期结束后进行组织学评估。根据卡方检验和Student-Newman-Keuls检验进行统计分析。
睾酮组20例（66.6%）患者症状有显著改善，安慰剂组21例（75%）患者症状有显著改善。两组之间未观察到统计学差异。少数病例观察到外观变化，无一例显示组织学改变。
凡士林软膏在治疗外阴硬化性苔藓方面与2%睾酮效果相同。
