Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.
J Am Coll Cardiol. 2010 Aug 17;56(8):662-6. doi: 10.1016/j.jacc.2010.03.063.
The aim of this study was to determine the impact of fat gain and its distribution on endothelial function in lean healthy humans.
Endothelial dysfunction has been identified as an independent predictor of cardiovascular events. Whether fat gain impairs endothelial function is unknown.
A randomized controlled study was conducted to assess the effects of fat gain on endothelial function. Forty-three normal-weight healthy volunteers were recruited (mean age 29 years; 18 women). Subjects were assigned to gain weight (approximately 4 kg) (n=35) or to maintain weight (n=8). Endothelial function (brachial artery flow-mediated dilation [FMD]) was measured at baseline, after fat gain (8 weeks), and after weight loss (16 weeks) for fat gainers and at baseline and follow-up (8 weeks) for weight maintainers. Body composition was measured by dual-energy X-ray absorptiometry and abdominal computed tomographic scans.
After an average weight gain of 4.1 kg, fat gainers significantly increased their total, visceral, and subcutaneous fat. Blood pressure and overnight polysomnography did not change after fat gain or loss. FMD remained unchanged in weight maintainers. FMD decreased in fat gainers (9.1+/-3% vs. 7.8+/-3.2%, p=0.003) but recovered to baseline when subjects shed the gained weight. There was a significant correlation between the decrease in FMD and the increase in visceral fat gain (rho=-0.42, p=0.004), but not with subcutaneous fat gain (rho=-0.22, p=0.15).
In normal-weight healthy young subjects, modest fat gain results in impaired endothelial function, even in the absence of changes in blood pressure. Endothelial function recovers after weight loss. Increased visceral rather than subcutaneous fat predicts endothelial dysfunction. (Fat Gain and Cardiovascular Disease Mechanisms; NCT00589498).
本研究旨在确定在瘦健康人群中，脂肪增加及其分布对内皮功能的影响。
内皮功能障碍已被确定为心血管事件的独立预测因子。脂肪增加是否会损害内皮功能尚不清楚。
进行了一项随机对照研究，以评估脂肪增加对内皮功能的影响。招募了 43 名正常体重的健康志愿者（平均年龄 29 岁；18 名女性）。受试者被分为增重（约 4 公斤）组（n=35）或维持体重组（n=8）。在基线、脂肪增加 8 周后和脂肪增加者体重减轻 16 周后测量内皮功能（肱动脉血流介导的扩张 [FMD]），以及在基线和随访 8 周后测量维持体重者的内皮功能。使用双能 X 射线吸收法和腹部计算机断层扫描测量身体成分。
在平均体重增加 4.1 公斤后，脂肪增加者的总脂肪、内脏脂肪和皮下脂肪显著增加。血压和夜间多导睡眠图在脂肪增加或减少后没有变化。FMD 在体重维持者中保持不变。脂肪增加者的 FMD 下降（9.1+/-3%比 7.8+/-3.2%，p=0.003），但当受试者减轻体重时恢复到基线。FMD 的下降与内脏脂肪增加呈显著相关性（rho=-0.42，p=0.004），但与皮下脂肪增加无关（rho=-0.22，p=0.15）。
在正常体重的年轻健康受试者中，适度的脂肪增加会导致内皮功能受损，即使血压没有变化。体重减轻后内皮功能恢复。内脏脂肪的增加而不是皮下脂肪的增加预测内皮功能障碍。（脂肪增加与心血管疾病机制；NCT00589498）。
