Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
J Perinatol. 2011 Apr;31(4):246-50. doi: 10.1038/jp.2010.111. Epub 2010 Aug 12.
The aim of this study was to assess the genetic effects of the vascular endothelial growth factor (VEGF) pathway on retinopathy of prematurity (ROP).
A prospective study from a tertiary center that enrolled 204 Japanese infants (<35 weeks of gestational age (GA)) having no anomalies. ROP developed in 127, but not in 77 infants. The relative severity was defined as non-severe, moderate and severe ROP for GA, based on the staging criteria. VEGF (g.-634G>C, g.+13553C>T) and VEGF-receptor (KDR g.+4422(AC)11 to 14, Flt-1 c.+6724(TG)13 to 23) gene polymorphisms and clinical variables were assessed by uni/multivariate analyses.
The frequency of polymorphisms did not differ between ROP and non-ROP patients. The TT genotype of g.+13553 showed a higher odds ratio for non-severe ROP than CC genotype (P=0.006). Multivariate analyses indicated that low birth weight, blood transfusion and respiratory distress syndrome, but not polymorphisms, were the risk factors of advanced ROP (≥ stage 3).
A genotype of the VEGF pathway weakly affects the severity of ROP compared with other clinical factors.
本研究旨在评估血管内皮生长因子（VEGF）通路的遗传效应对早产儿视网膜病变（ROP）的影响。
这是一项来自三级中心的前瞻性研究，共纳入 204 名无畸形的日本早产儿（<35 周胎龄（GA））。127 名婴儿发生 ROP，而 77 名婴儿未发生。ROP 的相对严重程度根据分期标准定义为 GA 的非重度、中度和重度 ROP。通过单变量/多变量分析评估 VEGF（g.-634G>C、g.+13553C>T）和 VEGF 受体（KDR g.+4422(AC)11 至 14、Flt-1 c.+6724(TG)13 至 23）基因多态性和临床变量。
ROP 和非 ROP 患者的多态性频率无差异。g.+13553 的 TT 基因型发生非重度 ROP 的优势比高于 CC 基因型（P=0.006）。多变量分析表明，低出生体重、输血和呼吸窘迫综合征是 ROP 进展（≥3 期）的危险因素，而不是多态性。
与其他临床因素相比，VEGF 通路的基因型对 ROP 的严重程度有一定影响。
