Hăşmăşanu Monica G, Procopciuc Lucia M, Matyas Melinda, Zonda Gabriela I, Zaharie Gabriela C
Department of Neonatology, Iuliu Haţieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.
Department of Medical Biochemistry, Iuliu Haţieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Children (Basel). 2023 Apr 19;10(4):744. doi: 10.3390/children10040744.
(1) Background: Vascular endothelial growth factor (VEGF) is essential in vasculo- and angiogenesis due to its role in endothelial cell proliferation and migration. As a vascular proliferative factor, VEGF is one of the hallmarks of cancer and, in adult populations, the relationship between genetic polymorphism and neoplasm was widely investigated. For the neonatal population, only a few studies attempted to uncover the link between the genetic polymorphism of VEGF and neonatal pathology, especially related to late-onset complications. Our objective is to evaluate the literature surrounding VEGF genetic polymorphisms and the morbidity of the neonatal period. (2) Methods: A systematic search was initially conducted in December 2022. The PubMed platform was used to explore MEDLINE (1946 to 2022) and PubMed Central (2000 to 2022) by applying the search string ((VEGF polymorphism*) and newborn*). (3) Results: The PubMed search yielded 62 documents. A narrative synthesis of the findings was undertaken considering our predetermined subheadings (infants with low birth weight or preterm birth, heart pathologies, lung diseases, eye conditions, cerebral pathologies, and digestive pathologies). (4) Conclusion: The VEGF polymorphisms seem to be associated with neonatal pathology. The involvement of VEGF and VEGF polymorphism has been demonstrated for retinopathy of prematurity.
(1) 背景：血管内皮生长因子（VEGF）在血管生成和血管新生中至关重要，因为它在内皮细胞增殖和迁移中发挥作用。作为一种血管增殖因子，VEGF是癌症的标志之一，在成年人群中，基因多态性与肿瘤之间的关系得到了广泛研究。对于新生儿群体，只有少数研究试图揭示VEGF基因多态性与新生儿病理学之间的联系，特别是与迟发性并发症相关的联系。我们的目的是评估围绕VEGF基因多态性和新生儿期发病率的文献。(2) 方法：最初于2022年12月进行了系统检索。通过应用检索词（(VEGF polymorphism*) 和newborn*），使用PubMed平台探索MEDLINE（1946年至2022年）和PubMed Central（2000年至2022年）。(3) 结果：PubMed检索产生了62篇文献。考虑到我们预先确定的副标题（低出生体重或早产婴儿、心脏疾病、肺部疾病、眼部疾病、脑部疾病和消化系统疾病）对研究结果进行了叙述性综合分析。(4) 结论：VEGF基因多态性似乎与新生儿病理学相关。VEGF和VEGF基因多态性与早产儿视网膜病变的关联已得到证实。
