二维纸质网络中的化学信号放大
Chemical signal amplification in two-dimensional paper networks.
作者信息
Fu Elain, Kauffman Peter, Lutz Barry, Yager Paul
机构信息
Box 355061, Department of Bioengineering,,University of Washington, Seattle, WA, USA; Fax:206-616-3928; Tel: 206-685-9891.
出版信息
Sens Actuators B Chem. 2010 Aug 6;149(1):325-328. doi: 10.1016/j.snb.2010.06.024.
Abstract
Two-dimensional paper networks (2DPNs) hold great potential for extending the utility of paper-based chemical and biochemical diagnostics at a cost and ease-of-use that is comparable to conventional lateral flow strips. 2DPNs enable the automated sequential delivery of multiple reagents to a detection region with a single user activation step, and therefore have the potential to extend the processing capabilities of inexpensive paper-based assays with comparable ease of use to conventional lateral flow tests. In this communication, we used a simple 3 inlet 2DPN to perform signal amplification of a colloidal gold label using a gold enhancement solution, thus demonstrating the capability of 2DPNs to perform processes that can improve limits of detection.
摘要
二维纸质网络（2DPN）在扩展基于纸张的化学和生化诊断工具的效用方面具有巨大潜力，其成本和易用性与传统侧向流动试纸条相当。2DPN能够通过单个用户激活步骤将多种试剂自动顺序递送至检测区域，因此有潜力以与传统侧向流动测试相当的易用性扩展廉价纸质检测的处理能力。在本通讯中，我们使用了一种简单的三入口2DPN，利用金增强溶液对胶体金标记进行信号放大，从而证明了2DPN执行可改善检测限的过程的能力。
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