Deftos L J
Department of Medicine, University of California San Diego.
Endocr Rev. 1991 May;12(2):181-7. doi: 10.1210/edrv-12-2-181.
CgA is a 49 kilodalton protein that is present in the secretory granules of most endocrine and many neuroendocrine cells. Detection of CgA in cells by immunocytochemistry and measurement of CgA in serum by immunoassay can serve as tissue and serum markers for CgA-producing tumors. CgA is of diagnostic value in classical endocrine tumors, in hormone-negative tumors, and in endocrine tumors in which other diagnostic procedures have their limitations. Although the biological function of CgA is yet unknown, it may serve as a precursor molecule, like POMC, for a family of biologically active peptides. CgA is an important new tool for the endocrinologist in the diagnosis and management of patients with endocrine and neuroendocrine tumors.
嗜铬粒蛋白A是一种49千道尔顿的蛋白质，存在于大多数内分泌细胞和许多神经内分泌细胞的分泌颗粒中。通过免疫细胞化学检测细胞中的嗜铬粒蛋白A以及通过免疫测定法测量血清中的嗜铬粒蛋白A，可作为产生嗜铬粒蛋白A的肿瘤的组织和血清标志物。嗜铬粒蛋白A在经典内分泌肿瘤、激素阴性肿瘤以及其他诊断方法存在局限性的内分泌肿瘤中具有诊断价值。尽管嗜铬粒蛋白A的生物学功能尚不清楚，但它可能像阿黑皮素原一样，作为一类生物活性肽家族的前体分子。嗜铬粒蛋白A是内分泌学家诊断和管理内分泌及神经内分泌肿瘤患者的重要新工具。
