Institut Curie, Centre de recherche, CNRS, UMR144, Paris, France.
Semin Cell Dev Biol. 2010 Dec;21(9):874-80. doi: 10.1016/j.semcdb.2010.08.006. Epub 2010 Aug 11.
A critical and irreversible step in the cell division cycle is cytokinesis which physically separates the two daughter cells. This event is consequently subject to tight spatial and temporal regulation. This review focuses on the spatial regulatory mechanisms controlling the position of the division plane. Studies performed in prokaryotic and eukaryotic systems have revealed that various signal-emitting spatial cues - mitotic spindle, nucleus, nucleoid or cell tips - can favour or inhibit the assembly of the cytokinetic apparatus in their vicinity. Most often, several mechanisms operate in parallel to integrate spatial information and promote faithful genome segregation as well as proper cytoplasmic division. We primarily describe the spatial regulatory mechanisms operating in the fission yeast model system, where a detailed molecular understanding of cytokinesis has been achieved. In this system, spatial regulations target a major factor controlling the position of the division plane, the anillin-like protein Mid1. These mechanisms are then compared to spatial regulatory mechanisms prevailing in animal cells and rod-shaped bacteria.
细胞分裂周期中的一个关键且不可逆的步骤是胞质分裂，它将两个子细胞物理分离。因此，这一事件受到严格的时空调控。本综述重点介绍了控制分裂平面位置的空间调节机制。在原核和真核系统中进行的研究表明，各种信号发射的空间线索——有丝分裂纺锤体、核、拟核或细胞尖端——可以促进或抑制细胞分裂装置在其附近的组装。通常，多种机制并行运作，以整合空间信息，促进基因组的准确分离和细胞质的适当分裂。我们主要描述了在裂殖酵母模型系统中起作用的空间调节机制，在该系统中，细胞分裂的详细分子机制已经被阐明。在这个系统中，空间调节针对的是控制分裂平面位置的一个主要因素，即肌球蛋白样蛋白 Mid1。然后将这些机制与在动物细胞和杆状细菌中起作用的空间调节机制进行比较。
