Department of Radiation Oncology, University of Heidelberg, Heidelberg.
Department of Hematology and Oncology, University of Mannheim, Mannheim.
Ann Oncol. 2011 Mar;22(3):524-535. doi: 10.1093/annonc/mdq387. Epub 2010 Aug 13.
Anti-epidermal growth factor receptor treatment strategies, i.e. monoclonal antibodies such as cetuximab and panitumumab, or epidermal growth factor receptor (EGFR) small molecule tyrosine kinase inhibitors, such as erlotinib and gefitinib, have expanded the treatment options for different tumor types. Dermatologic toxic effects are the most common side-effects of EGFR inhibitor therapy. They can profoundly affect the patient's quality of life.
The aim of this study was to provide interdisciplinary expert recommendations on how to treat patients with skin reactions undergoing anti-EGFR treatment.
An expert panel from Germany with expertise in medical oncology, dermatology or clinical pharmacology was convened to develop expert recommendations based on published peer-reviewed literature.
The expert recommendations for the state-of-the-art treatment of skin reactions induced by EGFR inhibitor therapy include recommendations for diagnostics and grading as well as grade-specific and stage-adapted treatment approaches and preventive measures. It was concluded that EGFR-inhibitor-related dermatologic reactions should always be treated combining basic care of the skin and a specific therapy adapted to stage and grade of skin reaction. For grade 2 and above, specific treatment recommendations for early- and later-stage skin reactions induced by EGFR-inhibitor therapy were proposed.
This paper presents a German national expert opinion for the treatment of skin reactions in patients receiving EGFR inhibitor therapy.
抗表皮生长因子受体（EGFR）治疗策略，如西妥昔单抗和帕尼单抗等单克隆抗体，或厄洛替尼和吉非替尼等 EGFR 小分子酪氨酸激酶抑制剂，已经扩展了不同肿瘤类型的治疗选择。皮肤毒性反应是 EGFR 抑制剂治疗最常见的副作用。它们会深刻影响患者的生活质量。
本研究旨在为接受 EGFR 治疗的皮肤反应患者提供跨学科的专家建议。
德国召集了来自医学肿瘤学、皮肤病学或临床药理学领域的专家组成专家组，根据已发表的同行评议文献制定专家建议。
针对 EGFR 抑制剂治疗引起的皮肤反应的最新治疗的专家建议包括诊断和分级以及针对特定等级和阶段的治疗方法和预防措施的建议。结论是，应始终结合皮肤的基本护理和针对皮肤反应的特定治疗来治疗 EGFR 抑制剂相关的皮肤反应。对于 2 级及以上的皮肤反应，提出了针对 EGFR 抑制剂治疗引起的早期和晚期皮肤反应的具体治疗建议。
本文提出了德国针对接受 EGFR 抑制剂治疗的患者皮肤反应治疗的国家专家意见。
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