Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.
Med Oral Patol Oral Cir Bucal. 2011 Jan 1;16(1):e29-32. doi: 10.4317/medoral.16.e29.
Oral contraceptives (OCP) are highly effective, safe and widely used. Higher exposure to endogenous and exogenous estrogens is generally thought to increase the risk of breast cancer. Therefore, this study was conducted to determine if oral contraceptive use affected the expression of CA 15-3, CEA and C-erb B-2 in the saliva of healthy women.
The participants consisted of 87 healthy women (43 controls and 44 using oral contraceptives) ranging in age from 20 to 54 years. The volunteers participated by giving one - time stimulated whole saliva samples. Then the samples were analysed for CA 15-3, CEA and C-erb B-2 concentrations.
The student t-test was used to compare group means for variables with comparable variability. The mean of C-erb B-2, CEA, and CA 15-3 concentrations (in the case and control groups) was (1.93, 1.70), (34.46, 31.62) and (12.58, 16.19) respectively. These differences were not statistically significant.
Our findings suggest that the levels of the cancer biomarkers C-erb B-2, CEA and CA 15-3 were not affected by increased levels of estrogens in the body.
口服避孕药（OCP）具有高效、安全和广泛应用的特点。一般认为，内源性和外源性雌激素暴露增加会增加乳腺癌的风险。因此，本研究旨在确定口服避孕药的使用是否会影响健康女性唾液中 CA 15-3、CEA 和 C-erb B-2 的表达。
参与者包括 87 名年龄在 20 至 54 岁之间的健康女性（43 名对照组和 44 名口服避孕药组）。志愿者通过提供一次性刺激全唾液样本参与研究。然后分析样本中 CA 15-3、CEA 和 C-erb B-2 的浓度。
使用学生 t 检验比较具有可比变异性的组均值。C-erb B-2、CEA 和 CA 15-3 浓度的平均值（病例组和对照组）分别为（1.93、1.70）、（34.46、31.62）和（12.58、16.19）。这些差异没有统计学意义。
我们的研究结果表明，癌症生物标志物 C-erb B-2、CEA 和 CA 15-3 的水平不受体内雌激素水平升高的影响。
