Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Med Oral Patol Oral Cir Bucal. 2009 Oct 1;14(10):e521-4. doi: 10.4317/medoral.14.e521.
The aim of this study was to assess the relationship between serum and saliva levels of cancer antigen (CA) 15-3 and to compare them between women with and without breast cancer.
A case-control study was carried out on 61 women aged 28-69 years, including women with and without breast cancer (26 as part of the case study and 35 as part of the control group) conducted at the Emam Khomeini Hospital, Tehran University of Medical Sciences. CA 15-3 levels were assayed in serum and unstimulated whole saliva by EIA. Unpaired t-test, one-way ANOVA and Pearson correlation were used as statistical analysis.
The salivary and serological levels of CA 15-3 in the cancer patients were significantly higher (P <0.01) than the salivary and serum levels of healthy controls. They were also higher in stage 2 than in stage 1 in cancer patients. However, the saliva flow rate was significantly lower in the cancer patients (P <0.01). There was a significant positive correlation between serum and saliva CA 15-3 concentration (r = 0.614) and also between serum concentration and saliva output of CA 15-3 (r = 0.541).
The results of the study suggest that salivary CA 15-3 may have potential use in the initial detection of breast cancer in women.
本研究旨在评估血清和唾液中癌症抗原（CA）15-3 的水平之间的关系，并比较乳腺癌患者和非乳腺癌患者之间的水平差异。
这是一项在德黑兰医科大学埃马姆霍梅尼医院进行的病例对照研究，共纳入 61 名年龄在 28-69 岁的女性，包括 26 名乳腺癌患者（病例组）和 35 名非乳腺癌患者（对照组）。采用 EIA 法检测血清和未刺激全唾液中的 CA 15-3 水平。采用非配对 t 检验、单因素方差分析和 Pearson 相关分析进行统计学分析。
癌症患者的唾液和血清 CA 15-3 水平明显高于健康对照组（P<0.01），且在癌症患者中，2 期患者的水平高于 1 期患者。然而，癌症患者的唾液流量明显较低（P<0.01）。血清和唾液 CA 15-3 浓度之间存在显著的正相关关系（r=0.614），血清浓度与唾液中 CA 15-3 分泌量之间也存在显著的正相关关系（r=0.541）。
研究结果表明，唾液 CA 15-3 可能具有用于女性乳腺癌早期检测的潜力。
