Shin Jung Won, Nam Kyung Mi, Choi Hye Ryung, Huh Sun Young, Kim Shin Woo, Youn Sang Woong, Huh Chang Hun, Park Kyoung Chan
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
Ann Dermatol. 2010 Aug;22(3):279-83. doi: 10.5021/ad.2010.22.3.279. Epub 2010 Aug 5.
Vitiligo is an acquired and progressive hypomelanotic disease that manifests as circumscribed depigmented patches on the skin. Although the precise mechanism remains to be elucidated, an imbalance of the oxidant/antioxidant system has been proposed as an important etiologic mechanism.
The objective of this study was to evaluate the oxidant/antioxidant status of vitiligo patients at the erythrocyte level.
Fifty-three vitiligo patients and 65 phototype-, age-, and sex-matched healthy controls were included in this study. Blood samples were collected from all subjects, and all patients were instructed to answer a questionnaire.
Erythrocyte levels of malondialdehyde (MDA) and glutathione (GSH) were measured. All patients were told to answer a questionnaire regarding their habitual behavior, including frequency of smoking and type of diet. We observed significantly lower levels of GSH in vitiligo patients, but the levels of MDA did not differ between patients and controls. Vitiligo patients who smoked showed significantly lower GSH levels compared to non-smoking patients, but the levels of MDA were unchanged between the 2 groups.
From our results, we conclude that reduced erythrocytic or systemic GSH levels constitute a distinctive feature in vitiligo patients regardless of disease activity.
白癜风是一种获得性、进行性色素减退性疾病，表现为皮肤上出现局限性色素脱失斑。尽管确切机制仍有待阐明，但氧化/抗氧化系统失衡被认为是一种重要的病因机制。
本研究的目的是评估白癜风患者红细胞水平的氧化/抗氧化状态。
本研究纳入了53例白癜风患者和65例肤色、年龄和性别匹配的健康对照者。采集了所有受试者的血样，并指导所有患者填写一份问卷。
测量了红细胞丙二醛（MDA）和谷胱甘肽（GSH）水平。告知所有患者填写一份关于其习惯行为的问卷，包括吸烟频率和饮食类型。我们观察到白癜风患者的GSH水平显著较低，但患者与对照组的MDA水平无差异。吸烟的白癜风患者与不吸烟患者相比，GSH水平显著较低，但两组间MDA水平无变化。
根据我们的结果，我们得出结论，无论疾病活动情况如何，红细胞或全身GSH水平降低是白癜风患者的一个显著特征。
