Kim Chi Yeon, Kim Jin Gu, Oh Chee Won
Department of Dermatology and Institute of Health Science, School of Medicine, Gyeongsang National University, Jinju, Korea.
Ann Dermatol. 2010 Aug;22(3):326-9. doi: 10.5021/ad.2010.22.3.326. Epub 2010 Aug 5.
Lichen sclerosus is a chronic inflammatory mucocutaneous disorder predominately affecting prepubertal girls and postmenopausal women. Isolated lichen sclerosus affecting the oral mucosa is exceedingly rare, and only 13 patients with biopsy-proved isolated oral disease have been reported in the literature. We report on a 7-year-old Korean girl with a well-demarcated 1.2x1.2 cm atrophic white plaque with an erythematous border and focal telangiectasia on the left vermillion lip, extending to the labial mucosa. No other cutaneous surfaces, including genitalia, were involved. An incisional biopsy of the plaque on the lip revealed a patchy lichenoid infiltrate of lymphocytes associated with sclerosis of the papillary dermis and a thinned epidermis consistent with a diagnosis of linear orofacial lichen sclerosus. Treatment with a short course of 1% pimecrolimus cream effectively prevented the progression of this lesion.
硬化性苔藓是一种慢性炎症性黏膜皮肤疾病，主要影响青春期前女孩和绝经后女性。孤立性硬化性苔藓累及口腔黏膜极为罕见，文献中仅报道了13例经活检证实的孤立性口腔疾病患者。我们报告了一名7岁韩国女孩，其左侧唇红缘有一个边界清晰的1.2×1.2厘米萎缩性白色斑块，伴有红斑边界和局灶性毛细血管扩张，延伸至唇黏膜。未累及包括生殖器在内的其他皮肤表面。唇部斑块的切开活检显示有淋巴细胞呈斑片状苔藓样浸润，伴有乳头真皮硬化和表皮变薄，符合线性口面部硬化性苔藓的诊断。短期外用1%吡美莫司乳膏治疗有效阻止了该病变的进展。
