Kelly Susan C, Helm Klaus F, Zaenglein Andrea L
Department of Dermatology, Lehigh Valley Hospital, Allentown, Pennsylvania, USA.
Pediatr Dermatol. 2006 Sep-Oct;23(5):500-2. doi: 10.1111/j.1525-1470.2006.00293.x.
Lichen sclerosus is a chronic inflammatory mucocutaneous disorder predominately affecting prepubertal girls and postmenopausal women. Isolated lichen sclerosus affecting the oral mucosa is exceedingly rare. Only 13 patients with biopsy-proved isolated oral disease have been reported in the literature. We report a 10-year-old Caucasian girl with a well-demarcated 1.5 cm x 1.2 cm atrophic white plaque with a violaceous border and focal telangiectases on the right inferior vermillion lip, extending on to the labial mucosa. No other cutaneous surfaces, including genitalia, were involved. Incisional biopsy of the plaque on the lip revealed a patchy lichenoid infiltrate of lymphocytes associated with sclerosis of the papillary dermis and a thinned epidermis consistent with a diagnosis of lichen sclerosus. Treatment with a short course of high potency topical corticosteroids likely prevented the progression of this lesion.
硬化性苔藓是一种慢性炎症性黏膜皮肤疾病，主要影响青春期前女孩和绝经后女性。孤立性硬化性苔藓累及口腔黏膜极为罕见。文献中仅报道了13例经活检证实的孤立性口腔疾病患者。我们报告了一名10岁的白种女孩，其右下红唇有一个边界清晰的1.5厘米×1.2厘米萎缩性白色斑块，边缘呈紫红色，并有局灶性毛细血管扩张，延伸至唇黏膜。未累及包括生殖器在内的其他皮肤表面。唇部斑块的切取活检显示有淋巴细胞呈斑片状苔藓样浸润，伴有乳头真皮硬化和表皮变薄，符合硬化性苔藓的诊断。短期使用高效局部皮质类固醇治疗可能预防了该病变的进展。
