Singh M, Singhal P K, Paul V K, Deorari A K, Sundaram K R, Ghorpade M D, Agadi A
Department of Paediatrics, All India Institute of Medical Sciences, New Delhi.
Indian J Med Res. 1991 Feb;94:6-10.
A total of 107 babies with hypoglycaemia were studied over a period of 15 months. Symptomatic hypoglycaemia was found in 43 while it was asymptomatic in the others. Asymptomatic hypoglycaemia occurred at a relatively earlier post-natal age (4.5 +/- 2.2 h), as compared to symptomatic hypoglycemia (18.5 +/- 5.4 h, P less than 0.001). The mean blood glucose in hypoglycaemic babies with seizures was found to be significantly lower (P less than 0.001) when compared to those with other features as well as asymptomatic ones. Hypoglycaemia lasted for a significantly longer duration in symptomatic babies as compared to those without symptoms (P less than 0.001). On neurodevelopment follow up the mental developmental index (MDI) and the psychomotor developmental index (PDI) of symptomatic babies with seizures were significantly lower (P less than 0.001) as compared to those with other features of hypoglycaemia as well as asymptomatic babies. The neurodevelopmental status of babies with symptoms other than seizures was also significantly poorer (P less than 0.001), when compared to asymptomatic hypoglycaemic babies. The duration of hypoglycaemia was directly related to the MDI (r = -0.74, y = 102.5 - 0.69x) and PDI (r = -0.81, y = 105.6 - 0.86x). This study indicates that there is a need to identify babies vulnerable to symptomatic hypoglycaemia more precisely.
在15个月的时间里，共对107名低血糖婴儿进行了研究。其中43名出现症状性低血糖，其余则为无症状性低血糖。与症状性低血糖（18.5±5.4小时，P<0.001）相比，无症状性低血糖发生在相对较早的出生后年龄（4.5±2.2小时）。与有其他特征以及无症状的低血糖婴儿相比，有惊厥的低血糖婴儿的平均血糖显著更低（P<0.001）。与无症状婴儿相比，症状性低血糖婴儿的低血糖持续时间显著更长（P<0.001）。在神经发育随访中，与有低血糖其他特征的婴儿以及无症状婴儿相比，有惊厥的症状性低血糖婴儿的智力发育指数（MDI）和精神运动发育指数（PDI）显著更低（P<0.001）。与无症状性低血糖婴儿相比，有惊厥以外症状的婴儿的神经发育状况也显著更差（P<0.001）。低血糖持续时间与MDI（r=-0.74，y=102.5-0.69x）和PDI（r=-0.81，y=105.6-0.86x）直接相关。这项研究表明，需要更精确地识别易发生症状性低血糖的婴儿。
