Paik Elizabeth J, Zon Leonard I
Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston 02115, USA.
Int J Dev Biol. 2010;54(6-7):1127-37. doi: 10.1387/ijdb.093042ep.
The model organism Danio rerio, also known as the zebrafish, is an excellent system for studying the developmental process of hematopoiesis. It is an ideal model for in vivo imaging, and it is useful for large-scale genetic screens. These have led to the discovery of previously unknown players in hematopoiesis, as well as helped our understanding of hematopoietic development. In this review, we will summarize hematopoiesis in the zebrafish and discuss how genetic approaches using the zebrafish system have helped to build our current knowledge in the field of hematopoiesis.
模式生物斑马鱼（学名Danio rerio）是研究造血发育过程的优秀系统。它是体内成像的理想模型，适用于大规模基因筛选。这些优势促成了造血过程中先前未知参与者的发现，也有助于我们对造血发育的理解。在这篇综述中，我们将总结斑马鱼的造血过程，并讨论利用斑马鱼系统的遗传学方法如何帮助构建我们目前在造血领域的知识。
