Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA.
Antioxid Redox Signal. 2011 Jan 15;14(2):203-5. doi: 10.1089/ars.2010.3227. Epub 2010 Oct 12.
As improvements in standard of living and advances in medicine have resulted in greater life expectancy, the relative proportion of elderly has continued to increase in human populations across the globe. The primary goal of aging research is to gain a better understanding of the series of events that lead to increased frailty and disease vulnerability with age. The direct study of human aging is an active area of research; however, the opportunity to conduct mechanistic studies and gain insights into the underlying biology is limited. In this special forum issue of Antioxidant & Redox Signaling, we present a selection of articles and reviews that illustrate some of the recent advances in primate aging research. The overarching goal of this work is to underscore the potential for mechanistic discovery that is presented by nonhuman primate models, and to promote studies that validate novel approaches and techniques in nonhuman primates before their adaptation for human health care.
随着生活水平的提高和医学的进步，人类的预期寿命不断延长，老年人在全球人口中的比例持续增加。衰老研究的主要目标是更好地了解导致脆弱性和易患病性随年龄增长的一系列事件。人类衰老的直接研究是一个活跃的研究领域；然而，进行机制研究并深入了解潜在生物学的机会是有限的。在本期《抗氧化剂与氧化还原信号》的特别论坛专刊中，我们精选了一些文章和综述，展示了灵长类动物衰老研究的最新进展。这项工作的总体目标是强调非人类灵长类动物模型所带来的机制发现潜力，并促进在将新方法和技术应用于人类医疗保健之前，在非人类灵长类动物中验证这些方法和技术的研究。
