衰老的表观遗传控制。
Epigenetic control of aging.
机构信息
Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island 02903, USA.
出版信息
Antioxid Redox Signal. 2011 Jan 15;14(2):241-59. doi: 10.1089/ars.2010.3250. Epub 2010 Nov 22.
Abstract
Organismal aging and longevity are influenced by many complex interacting factors. Epigenetics has recently emerged as another possible determinant of aging. Here, we review some of the epigenetic pathways that contribute to cellular senescence and age-associated phenotypes. Strategies aimed to reverse age-linked epigenetic alterations may lead to the development of new therapeutic interventions to delay or alleviate some of the most debilitating age-associated diseases.
摘要
生物体的衰老和长寿受到许多复杂相互作用因素的影响。最近，表观遗传学作为衰老的另一个可能决定因素出现了。在这里，我们回顾了一些导致细胞衰老和与年龄相关表型的表观遗传途径。旨在逆转与年龄相关的表观遗传改变的策略可能导致开发新的治疗干预措施，以延缓或减轻一些与年龄相关的最具破坏性的疾病。
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