Suzuki I, Kinoshita A, Tanaka H, Yadomae T
Laboratory of Immunopharmacology of Microbial Products, Tokyo College of Pharmacy, Japan.
Int J Immunopharmacol. 1991;13(2-3):147-54. doi: 10.1016/0192-0561(91)90092-l.
The effect of orally administered OK-432, a streptococcal preparation, on the function of peritoneal macrophages in mice was examined. The administration of OK-432 orally (1 KE or 2 KE, four times every three days) did not affect the numbers of both total peritoneal cells and macrophages recovered five days after the final administration. However, the macrophages exhibited an increase in their spreading ability. Other functions of the peritoneal macrophages including lysosomal enzyme activity, phagocytic activity and interleukin 1 (IL-1) production were also enhanced significantly by the oral administration of OK-432 (1 KE or 2 KE). The production of H2O2, however, was not affected by the same treatment with OK-432. The activation of peritoneal macrophages by orally administered OK-432 reported here may contribute to expansion of the clinical application of this drug.
研究了口服链球菌制剂OK-432对小鼠腹腔巨噬细胞功能的影响。口服OK-432（1KE或2KE，每三天给药四次）不影响末次给药五天后回收的腹腔总细胞数和巨噬细胞数。然而，巨噬细胞的铺展能力增强。口服OK-432（1KE或2KE）也显著增强了腹腔巨噬细胞的其他功能，包括溶酶体酶活性、吞噬活性和白细胞介素1（IL-1）的产生。然而，H2O2的产生不受相同的OK-432处理的影响。本文报道的口服OK-432对腹腔巨噬细胞的激活作用可能有助于扩大该药物的临床应用。
