Barratt G M, Raddassi K, Petit J F, Tenu J P
U.R.A. CNRS 1116, Université Paris-Sud, Orsay, France.
Int J Immunopharmacol. 1991;13(2-3):159-65. doi: 10.1016/0192-0561(91)90094-n.
Rat alveolar macrophages can be activated in vitro for cytostatic activity against tumor cells by MDP and LPS acting in synergy. MDP can be substituted for by analogs active as adjuvants. Macrophage activation correlates with an increased production of nitrite and citrulline. NG-monomethyl-L-arginine, a specific inhibitor of the L-arginine metabolism having nitrite and citrulline as end products, abolishes the cytostatic activity. We therefore conclude that, in this model, the main effector mechanism of the cytostatic activity is mediated by molecules derived from L-arginine through the newly described NOo-generating pathway.
鼠肺泡巨噬细胞在体外可被 MDP 和 LPS 协同作用激活，从而对肿瘤细胞产生细胞抑制活性。MDP 可被具有佐剂活性的类似物替代。巨噬细胞的激活与亚硝酸盐和瓜氨酸产量的增加相关。NG-单甲基-L-精氨酸是 L-精氨酸代谢的一种特异性抑制剂，其终产物为亚硝酸盐和瓜氨酸，它可消除细胞抑制活性。因此我们得出结论，在该模型中，细胞抑制活性的主要效应机制是由 L-精氨酸通过新描述的生成 NO 的途径衍生而来的分子介导的。
