Reisser D, Jeannin J F, Martin F
C R Seances Acad Sci III. 1982 Nov 8;295(8):485-8.
Muramyl dipeptide (MDP) is a synthetic adjuvant known to activate macrophages. We now report that rat peritoneal macrophages are rendered tumoricidal in vitro against tumor cells either when macrophages are preincubated for 24 hrs. with MDP or when MDP is added to the culture medium simultaneously with the tumor cells. MDP significantly increases the cytotoxic activity of macrophages activated in vivo with BCG.
胞壁酰二肽（MDP）是一种已知可激活巨噬细胞的合成佐剂。我们现在报告，当大鼠腹膜巨噬细胞与MDP预孵育24小时，或者当MDP与肿瘤细胞同时添加到培养基中时，它们在体外对肿瘤细胞具有杀肿瘤活性。MDP显著增强了用卡介苗在体内激活的巨噬细胞的细胞毒性活性。
